On 28 April 2022,
Paul Ignatius departed
Mayport, Florida, for a patrol in the US Sixth Fleet area of operations and a homeport shift to Naval Station Rota. On 17 June 2022,
Paul Ignatius arrived at her new homeport of in Rota, Spain. Her
Phalanx CIWS was moved to the forward mount and she received the
SeaRAM close-in weapon system on her aft mount. In October 2022,
Paul Ignatius conducted a routine patrol in the
Baltic Sea, where she was accompanied by the support ship . After the
2022 Nord Stream pipeline sabotage the ship remained deployed there to safeguard regional energy interests and to guard the areas of the pipeline sabotage. During this period, she embarked personnel from
diving,
salvage, and
explosive ordnance disposal (EOD) units to assist in security and assessment operations. On December 25, 2025,
Paul Ignatius participated in a
military operation against
Islamic State (ISIS) militants in northwest Nigeria, in collaboration with the
Nigerian government and
U.S. Africa Command (AFRICOM). The operation involved launching Tomahawk cruise missiles from the
Paul Ignatius in the
Gulf of Guinea, authorized by President
Donald Trump. ==References==