Yorktown departed
Hampton Roads on 13 December 1840, bound for the
Pacific. After calling at
Rio de Janeiro from 23 January to 5 February 1841, the sloop rounded
Cape Horn and arrived at
Valparaíso, Chile, on 20 March 1841. The ship operated along the Pacific coast of South America until 26 May, when she sailed from
Callao, Peru, bound for the Pacific isles. Looking after the interests of the American
whaling industry and of the nation's ocean commerce, she called at the
Marquesas, the
Society Islands, New Zealand, and the
Hawaiian Islands. After completing her mission in the South and Central Pacific, she departed
Honolulu on 6 November and headed for the coast of
Mexico.
Yorktown called at
Mazatlán before heading south to resume operations along the coast of South America. She continued her cruising – primarily out of Callao and Valparaíso – through the early fall of 1842, when she departed Callao on 23 September, bound for San Francisco, where she arrived on 27 October. Shifting to
Monterey on 11 November, the sloop called again at Mazatlán on the 22nd before she proceeded to Valparaiso.
Yorktown remained at that port until she got underway on 2 May 1843 for the east coast of the United States. After rounding Cape Horn and calling at Rio de Janeiro, she arrived at New York on 5 August. Six days later, the sloop was decommissioned. ==African slave duty==