game in the
EuroLeague in 2013
Peristeri Mantzaris began his professional career in the
Greek 2nd Division with
Peristeri, the team of his hometown. With Peristeri, he won the Greek 2nd Division championship in 2009.
Olympiacos On September 5, 2011, Mantzaris signed a four-year deal with the
top-tier level Greek Basket League and
EuroLeague club
Olympiacos Piraeus. He won both the EuroLeague and Greek League championships in 2012, being a useful tool for the team of coach
Dušan Ivković, especially due to his defensive ability. In January 2013, Mantzaris suffered a season-ending
knee injury, after rupturing the
anterior cruciate ligament in his right knee during a Greek Basket League derby against
PAOK Thessaloniki at
PAOK Sports Arena. Despite suffering the knee injury, he remained close to his teammates both in and out of the locker room in order to support them, as they won the
EuroLeague 2012–13 season championship. Mantzaris returned to action seven months later and in early October of the same year won the
FIBA Intercontinental Cup against
Pinheiros at
Ginásio José Corrêa, Brazil. In the two finals, he averaged 9 points, 4.5 rebounds and 3 assists, helping Olympiacos to celebrate the title. On 29 July 2014, Mantzaris extended his contract with Olympiacos through 2017. Mantzaris won the
Greek League 2014–15 season and
Greek League 2015–16 season national domestic championships with Olympiacos, under the instructions of former
Houston Rockets assistant coach,
Ioannis Sfairopoulos, being the starting
point guard of his team in both seasons. He also competed in the
2015 EuroLeague Finals versus
Real Madrid, in
Madrid, and in the
2017 EuroLeague Finals against
Fenerbahçe, in
Istanbul, however without earning the trophy. On June 16, 2017, Mantzaris signed a three-year contract extension with Olympiacos.
UNICS Kazan On July 20, 2019, Mantzaris was released from Olympiacos, after eight seasons, and signed with
UNICS Kazan of the
VTB United League and the
EuroCup, playing under fellow Greek coach
Dimitrios Priftis. He left in December, returning to Greece.
Promitheas Patras On December 30, 2019, Mantzaris returned to Greece and signed with
EuroCup side
Promitheas Patras. He averaged 10.5 points, 2.2 rebounds, 5.3 assists and 1.8 steals per game. On October 8, 2020, Mantzaris re-signed with the team.
Return to Peristeri On December 17, 2020, Mantzaris officially returned to Peristeri after nine years.
Stal Ostrów Wielkopolski On August 6, 2021, he has signed with
Stal Ostrów Wielkopolski of the
Polish Basketball League. In four games he averaged five points, five assists, 3.3 rebounds, and 1.3 steals per game.
Hapoel Eilat On October 4, 2021, Mantzaris signed with
Hapoel Eilat of the
Israeli Basketball Premier League. After the season ended, Mantzaris stated that the cooperation with coach
Aris Lykogiannis was not good, something that confirmed the poor communication between them.
Ionikos Nikaias On September 22, 2022, Mantzaris moved to
Ionikos Nikaias.
Venezuela On March 24, 2023, Mantzaris signed with Venezuelan club
Panteras de Miranda for the rest of the season.
Pallacanestro Roseto On September 4, 2023, Mantzaris signed with
Pallacanestro Roseto of the Italian third division.
Mykonos Mantzaris returned to Greece signing with
Mykonos for the 2024–2025 campaign and ultimately helped the club achieve promotion to the
1st division. ==National team career==