Each straight arteriole has a hairpin turn in the medulla and carries blood at a very slow rate – two factors crucial in the maintenance of
countercurrent exchange that prevent washout of the concentration gradients established in the renal medulla. The maintenance of this concentration gradient is one of the components responsible for the kidney's ability to produce concentrated
urine. On the descending portion of the vasa recta, sodium, chloride and urea are reabsorbed into the blood, while water is secreted. On the ascending portion, sodium chloride and urea are secreted into the interstitium, while water is reabsorbed. ==Clinical significance==