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Vasomotor center

The vasomotor center (VMC) is a portion of the medulla oblongata. Together with the cardiovascular center and respiratory center, it regulates blood pressure. It also has a more minor role in other homeostatic processes. Upon increase in carbon dioxide level at central chemoreceptors, it stimulates the sympathetic system to constrict vessels. This is opposite to carbon dioxide in tissues causing vasodilatation, especially in the brain. Cranial nerves IX and X both feed into the vasomotor centre and are themselves involved in the regulation of blood pressure.

Structure
The vasomotor center is a collection of integrating neurons in the medulla oblongata of the middle brain stem. The term "vasomotor center" is not truly accurate, since this function relies not on a single brain structure ("center") but rather represents a network of interacting neurons. This center is located in the Rostral ventrolateral medulla. Afferent fibres The vasomotor center integrates nerve impulses from many places via the solitary nucleus: • central chemoreceptorsaortic body chemoreceptors, which send impulses via the vagus nervescarotid body chemoreceptors, which send impulses via the glossopharyngeal nervesaortic arch and brachiocephalic artery high-pressure baroreceptors, which send impulses via the aortic nervecarotid sinus high-pressure baroreceptors, which send impulses via the glossopharyngeal nerves Efferent fibres The vasomotor center gives off sympathetic fibres through the spinal cord and sympathetic ganglia, which reach vascular smooth muscle. == Function ==
Function
The vasomotor center changes vascular smooth muscle tone. This acts to raise blood pressure. == Clinical significance ==
Clinical significance
Methyldopa acts on the vasomotor center, leading to selective stimulation of α2-adrenergic receptor. Guanfacine also causes the same stimulation. This reduces sympathetic tone to vascular smooth muscle. == History ==
History
The localization of vasomotor center was determined by Filipp Ovsyannikov in 1871. == See also ==
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