VAV2 is a
GEF for
RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation. Double
DH domain mutations, L342R/L343SVav2 function as a
dominant negative, blocking VAV2 GEF activity for RAC1 and
interact with
CD19 and
Grb2. ==References==