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VAV2

Guanine nucleotide exchange factor VAV2 is a protein that in humans is encoded by the VAV2 gene.

Interactions
VAV2 is a GEF for RAC1, specifically in fibroblasts VAV2 is necessary for integrin, but not growth factor–dependent activation of RAC leading to lamellipodia formation. Double DH domain mutations, L342R/L343SVav2 function as a dominant negative, blocking VAV2 GEF activity for RAC1 and interact with CD19 and Grb2. ==References==
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