The protein encoded by this gene is a member of the
rhomboid protease family of
integral membrane proteins. This family contains proteins that are related to
Drosophila rhomboid-1. Members of this family are found in both
prokaryotes and
eukaryotes and are thought to function as intramembrane
serine proteases. RHBDL2 functions as a
sheddase and is
localized to the
plasma membrane. Known substrates of RHBDL2 include
thrombomodulin and
epidermal growth factor; == References ==