Main characters ; : ,
Rina Satō (first drama CD) : Sumire is a student at Shirogane Girls Academy and is the newest member of the Venus Vanguard, despite being terribly scared of Viruses and the fact that she's been able to see ghosts most of her life, even when she was a child. While initially she cannot be of much help to Lucia, they eventually find out that whenever her body reacts to the special chemical used to defeat Viruses (the so-called Vaccine), she transforms into a "Berserker Mode", or a living Anti-Virus. With this strange ability, she becomes stronger and violent, and is capable of defeating Viruses with her bare hands, but when under the influence of this power, she cannot discern friend from foe, although over the course of the series she learns how to control her powers. She has feelings for Yoshiki, a boy she met in the park. ; : ,
Luci Christian (child)
Hitomi Nabatame (first drama CD) : Lucia is a strong girl who leads the fights against Viruses alongside the other members of the Venus Vanguard, sworn to fight and kill all Viruses. She is battlehardened and cold, but she shows a lot more facial expressions in the manga than in the anime. Her left eye holds a mysterious power, though is almost always covered with an eye patch. Use of her powers is taxing and wears her out, but can often be disastrous to her enemy in many ways. Her left arm has a symbol of the enchantment succeeded from her father. According to Sumire, Lucia often gives off a faint fragrance of roses, which is a scant memory of their intertwined pasts. She smokes in the manga. ; : ,
Tamio Ōki (first drama CD) : Soichiro is the guardian of Lucia, who loves her as if she were his real daughter-(the same goes for Lucia). Before Lucia was born, Soichiro was studying to become a
mage, along with Lilith and Lucif, who are Lucia's biological mother and father respectively. He harbored an unrequited love for Lilith, but never got close with her as she was in love with Lucif. ; : : A mysterious blonde girl who lives with Lucia and Soichiro. She loves chocolate and is often seen eating it. She has a twin named Layla and in the anime neither of them seem to age since they are soulless dolls created by Lucif and Soichiro's teacher; in the manga they are orphaned girls with a telepathic link to one another. She is a major character right from the beginning in the anime, but in the manga she does not show up until the fourth volume. In the English version of the anime, her name is rendered as "Laura". ; : : Yoshiki is a young man Sumire met one day in a park while he was reading a book. After a few more meetings together while exchanging books to read, Yoshiki starts to develop romantic feelings for Sumire. In the anime it is later discovered that he is actually one of Lucif's followers named Aion, he tries to take Sumire's fragment but stops because he truly cared for her, thus, he betrays Lucif, but Lucia, not knowing of his betrayal, kills him. In the manga, Aion is a sorcerer who seems to possess Lucif and later Yoshiki.
Supporting characters ; : :Nene is Sumire's female cousin who always tries to look out for her like an older sister. She often encourages her younger brother Riku in his attempts to ask Sumire out on a date. ; : :Riku is Nene's younger brother who has a crush on Sumire. Multiple times, Riku attempts to ask Sumire out on a date, but something always interferes, leaving him heartbroken each time. He has a timid personality, which makes it even more difficult to ask Sumire out. ; :,
Ai Nonaka (first drama CD) :Mika is one of Sumire's good friends and classmates. She has a tomboyish personality. ; :,
Emiri Katō (first drama CD) :Kyōko is another one of Sumire's good friends and classmates. ; :,
Kayo Sakata (first drama CD) :Shizu is another one of Sumire's good friends and classmates. ; : :Lilith is Lucia's mother who once worked under a mentor with Lucif and Soichiro to learn
magic arts, and in the anime after he died, their training ceased. Lilith fell in love with Lucif and eventually became pregnant with Lucia, though by the time she was born, Lucif was already gone on his quest for the True World. In the anime, a Virus allegedly killed Lilith when Lucia was still two years old. The Virus that killed her was Lucif so he could obtain her special fragment, although in the end, the fragment disappears. She killed herself to protect Lucia and the world that Lucif wanted to destroy.
Antagonists ; : :Sonoka is the current leader of the Virus, and has a particular focused interest in Lucia and Sumire. She is a devoted follower of Aion (Lucif in the anime) and his quest to find the True World. ; : :Ruka is a young girl who serves under Sonoka. She has a sadistic personality and has the power to control water and wind, though she states her specialty is electricity. In the English version of the anime, her name is rendered as "Luca". ; : :Guy is another one of Sonoka's henchman. He has a similar personality to Ruka, and he has the power to control fire and earth. ; : :Layla is Lola's twin. In the anime, after Lucif left to find the True World, Layla went with him and Lola stayed with Soichiro and Lilith. In the anime, Layla loves
konpeito candy as much as Lola loves chocolate; in the manga, both twins are ardent fans of
Pocky-like sticks, and are often seen munching on them. While in the anime, she is rather passive; in the manga, she gives off a more sinister presence. ; : :Lucif is Lucia's father who, before she was born, left to find the path to the True World. His past is filled with mysteries, and Soichiro refuses to talk about the subject with Lucia. In the anime, it is thought he turned himself into a Virus so he could obtain the True World. In the manga, it appears he was possessed by Aion. ==Media==