The first two seasons follow the life of Sara Aguilar Bermúdez (
Blanca Soto), an exceptionally happy woman who has all she could wish for in life, although her life changes forever when her fiancée Vicente Acero (
Damián Alcázar) is killed on their wedding day. After the petitions of their seven year-old son, Salvador, the couple is set to marry when a group of hitmen attacks the wedding and murders Vicente. Sara is forced to confront that Vicente was not who she believed. Sara and her son flee from the enemies of her deceased husband and attempt to survive. In the process, Sara becomes the great "Señora de Acero" in order to exact revenge on all those who have hurt her and her son.
In season two, after serving five years in prison, Sara hopes to be released on a lack of evidence. However, the president of Mexico sentences Sara to 25 years in prison at the request of his private secretary Berta Aguilar (
Luciana Silveyra). The hatred of a resentful sister, the political ambitions of a corrupt president, and other twists of destiny cause Señora Acero to fall into the hands of her mortal enemy, El Teca Martinez. For the second time, Sara must say goodbye to her son, Salvador (
Michel Duval) and the great love of her lie, Manuel Caicedo (
Lincoln Palomeque). Season three, takes place three years after Sara and Teca death. It tells the story of Vicenta "La Coyote" Rigores (
Carolina Miranda), one of the most courageous, respected and feared
coyotes on the border between Mexico and the United States. In significant demand by migrants seeking to cross the border, Vicenta is one of the most famous and feared women in northern Mexico, with a reputation for protecting migrants with her life from capture by immigration officials, as well as cartels who use migrants as slaves in the production and distribution of drugs. Vicenta is also one of the most wanted women by
Homeland Security, particularly by officer Daniel Phillips (
Luis Ernesto Franco), and other coyotes, who are threatened by her dominance in the business. La Coyote does not know her true parentage until her mother, on her deathbed, reveals that she is the illegitimate daughter of
narco and former commander Vicente Acero, and half-sister of Salvador, who is presumed to be the sole heir of the Acero dynasty. Vicenta's journey is complicated by Governor of Chihuahua, Chucho Casares (
Sergio Goyri), who is her mother's murderer and one of the heads of the most powerful arms trafficking rings in northern Mexico. Casares is also the father of Abelardo (Adrián Di Monte), the love of Vicenta's life. For La Coyote, the last name of Acero could be her salvation or her death sentence, but what is clear is that she is the only, and the second, Señora Acero.
In season four, Vicenta Acero is wanted by the governments of Mexico and the United States as her family is the main suspect in the death of Governor Chucho Casáres. Vicenta's brother Salvador is taken to jail after leaving the hotel wher ehe was hiding. Vicenta and Daniel are followed by the head of the
Department of National Security, Indira Cárdenas (
Gaby Espino), and the border patrol of the state of
Texas in an attempt to prevent the pair from continuing to cross immigrants at the border. In addition, Colombian drug trafficker Julián Romero (
Diego Cadavid) arrives in
Mexico to avenge the death of his relatives and his mother, Briceida Montero. Julián is obsessed with finding Vicenta to exact his revenge against Salvador and El Gallo (
Óscar Priego).
In season five, Vicenta Acero (Carolina Miranda), who is eight months pregnant when must bury her husband Daniel who has died after six months in
a coma. During Daniel's funeral, Vicenta communicates anonymously with
FBI agent Alberto Fuentes (
David Chocarro) to inform him that her husband's murderer is at the funeral. After tracing the call, Alberto arrives at the funeral and realizes that it was a false alarm. During an argument, Vicenta begins showing signs of labor and gives birth with Alberto assisting her. Alberto develops a deep bond with Vicenta's son. Six years later, the Acero family has left behind their life of money laundering, drug trafficking, and migrant crossing and have dedicated themselves to horse breeding, with El Gallo and Josefina dedicated to politics.
El Teca (
William Miller), who supposedly died at the hands of
Salvador Acero (Michel Duval) 5 years ago, returns after spending six years in a United States prison to get revenge on the Acero family by killing Vicenta's son. With the reappearance of Teca, the family is forced to flee their calm and isolated life. Vicenta makes the difficult decision to flee her new life and new love with her child. She meets Lucas Iglesias (Guillermo Zulueta), a hippie who gives her repose in a beachside inn where he works. Vicenta meets La Mecha (
María Rojo) who becomes a surrogate mother for Vicenta, and Nancy (
Patricia Manterola)), who becomes her best friend. La Tuti (
Ana Lucía Domínguez) owns a club for exotic dancers and, thanks to the success of the business, has managed to keep her son out of Mexico, although she must always be accompanied by bodyguards to avoid being extorted and her son, Álvaro, being kidnapped by El Teca. In an effort to defend their children, Vicenta and La Tuti join forces to stop El Teca. ==Cast and characters==