Early career Luque made his professional mixed martial arts debut in June 2009. He compiled a record of 7–4–1, competing for various regional promotions in Brazil before trying out for
The Ultimate Fighter in early 2014.
The Ultimate Fighter In February 2015, it was announced that Luque was one of the fighters selected to be on
The Ultimate Fighter: American Top Team vs. Blackzilians. In his first fight on the show, Luque faced
Nathan Coy. He won the fight by submission in the second round. In the semifinals, Luque faced off against
Hayder Hassan. He lost the fight via split decision.
Ultimate Fighting Championship Luque made his official debut for the promotion on July 12, 2015, at
The Ultimate Fighter 21 Finale, where he faced fellow castmate
Michael Graves. He lost the fight via unanimous decision. Luque next faced
Hayder Hassan in a rematch on December 19, 2015, at
UFC on Fox 17. He won the fight by submission in the first round and was awarded a
Performance of the Night bonus. Luque faced
Álvaro Herrera on July 7, 2016, at
UFC Fight Night 90. He won the fight via submission in the second round. Luque faced
Héctor Urbina on September 24, 2016, at
UFC Fight Night 95. Luque won the fight via first-round knockout, thereby earning his second Performance of the Night bonus. Luque returned to face
Belal Muhammad on November 12, 2016, at
UFC 205. He won the fight via knockout in the first round. Luque faced
Leon Edwards on March 18, 2017, at
UFC Fight Night 107. He lost the fight by unanimous decision. Luque faced
Niko Price, replacing an injured
Luan Chagas on 11 day notice, on October 28, 2017, at
UFC Fight Night 119. After knocking Price down, Luque won the fight by submission via D'Arce choke midway through the second round. Luque faced
Chad Laprise on May 19, 2018, at
UFC Fight Night 129. He won the fight via knockout in the first round. Luque faced promotional newcomer
Jalin Turner on October 6, 2018, at
UFC 229. He won the fight via knockout in the first round. Luque faced
Bryan Barberena on February 17, 2019, at
UFC on ESPN 1. After two competitive rounds that saw both men rock each other, Luque won the fight by TKO at the end of the third round after knocking Barberena down with a knee and finishing with punches. With this win, he became the first man to give Barberena his first stoppage loss by TKO. This fight earned him the
Fight of the Night award. Luque was expected to face
Neil Magny on May 18, 2019, at
UFC Fight Night 152. However, it was reported on May 13, 2019, that Magny pulled out of the bout due to testing positive for Di-Hydroxy-LGD-4033, and he was replaced by newcomer
Derrick Krantz. Luque won the fight via technical knockout in round one. Luque faced
Mike Perry on August 10, 2019, at
UFC on ESPN+ 14. He won the fight via split decision. This fight earned him the
Fight of the Night award. Luque faced
Stephen Thompson on November 2, 2019, at
UFC 244. He lost the fight via unanimous decision. This fight earned him the
Fight of the Night award. Luque was scheduled to face
Randy Brown on April 11, 2020, at
UFC Fight Night: Overeem vs. Harris. Due to the
COVID-19 pandemic, the event was eventually postponed. In a quick turnaround, Luque was scheduled to face
Niko Price in a rematch on April 18, 2020, at
UFC 249. However, on April 9,
Dana White, the president of UFC announced that this event was postponed and the bout eventually took place on May 9, 2020. He won the fight via technical knockout due to doctor stoppage in round three. The bout with
Randy Brown was rescheduled and took place on August 1, 2020, at
UFC Fight Night 173. Utilizing low kicks and dropping Brown multiple times, Luque eventually won the fight via knockout in the second round. This win earned him the
Performance of the Night award. Luque faced
Tyron Woodley on March 27, 2021, at
UFC 260. After hurting Woodley multiple times on the feet, Luque won the fight via D'Arce choke submission in round one. This fight earned him the
Fight of the Night award. Luque faced
Michael Chiesa on August 7, 2021, at
UFC 265. He won the fight via D'Arce choke submission in round one. This fight earned him the
Performance of the Night award. Luque was the emergency backup for the
UFC Welterweight Championship rematch between
Kamaru Usman and
Colby Covington in the main event of
UFC 268. However, Luque weighed in at 172.2 pounds, 2.2 pounds over the welterweight limit. Usman and Covington both made weight and the championship bout proceeded as scheduled. Luque faced
Belal Muhammad in a rematch on April 16, 2022, at
UFC on ESPN 34. He lost the fight via unanimous decision. Luque faced
Geoff Neal on August 6, 2022, at
UFC on ESPN 40. He lost the fight via knockout in round three. Luque was scheduled to face
Rafael dos Anjos on July 15, 2023, at
UFC on ESPN 49. However, the pair was moved to instead fight on August 12, 2023, at
UFC on ESPN: Luque vs. dos Anjos for unknown reasons. Luque won the fight via unanimous decision. Luque was scheduled to face
Ian Machado Garry on December 16, 2023, at
UFC 296. However, the bout was scrapped after Garry withdrew due to contracting
pneumonia the week of the event. Luque was scheduled to face
Sean Brady on March 30, 2024, at
UFC on ESPN 54. However, Brady indicated he never signed a bout agreement due to dealing with an injury, and was replaced by
Joaquin Buckley. Luque lost the fight via technical knockout in round two. Luque was scheduled to face former
WEC and
Strikeforce Welterweight Champion Nick Diaz on August 3, 2024 at
UFC on ABC 7. However, due to travel issues, the bout was postponed and was re-scheduled to take place on December 7, 2024 at
UFC 310. In turn, Diaz withdrew from the bout for unknown reasons and was replaced by
Themba Gorimbo. Luque won the fight via an anaconda choke submission under one minute into the first round. This fight earned him another
Performance of the Night award. Luque faced
Kevin Holland on June 7, 2025 at
UFC 316. He lost the fight via a D'Arce choke submission in the second round. Luque was scheduled to face
Santiago Ponzinibbio on October 11, 2025, at
UFC Fight Night 261. However, Ponzinibbio was forced to pull out from the event due to injury, and was replaced by
Joel Álvarez. Luque lost the fight by unanimous decision. Returning to the middleweight division, Luque was scheduled to face
Kyle Daukaus on April 11, 2026 at
UFC 327. However, Daukaus withdrew after being re‑scheduled for the
UFC Freedom 250 event in June and was replaced by former interim
UFC Middleweight Championship challenger
Kelvin Gastelum. Luque won the fight via an anaconda choke submission in the first round. ==Personal life==