He married Susana Paterno y Ramos, who grew up in
Pangil, Laguna and was a poor relation to her own Manila relatives, the Paternos of Quiapo and
Santa Cruz, Manila. She was a dressmaker to the prominent Cuyugan and Catigbac families, established a jewelry shop with the Salgado family of Pampanga, and dabbled in real estate. Before the war she acquired an hacienda in
Canlubang,
Laguna. She was responsible for the purchase of the Madrigal property where the old Jai Alai fronton used to stand, as well as buildings near her aunts' mansions on
Calle Hidalgo,
Quiapo, Manila and its adjacent streets. She urged her husband to invest in Hacienda de Mandaluyong even when her husband did not agree to be a major investor without control of the partnership built by Francisco Ortigas Jr. Susana foresaw that upon her husband's eventual divestment, the Ortigas clan would have to surrender large chunks of their property in payment. That property became what is now known as Corinthian Gardens and Arcadia Village in
Pasig where even a small lot commands millions today. She obtained lots in
Wack-Wack Golf Club which eventually devolved to her daughter Josefina. Further, she recognized the possibilities of
Alabang,
Muntinlupa. Susana Heights, an almost 400-hectare lot originally, devolved to her daughter Maria Luisa's side. Today,
Ayala Alabang's mango trees are her visible legacies in the mini-city, which features schools, Madrigal Business Park, and even a Polo field named after the family. Her descendants receive rents from the centrally located commercial real estate properties she acquired. In contrast, Vicente preferred non-real estate investments. He was frightened at how agricultural holdings like haciendas owned by great Spanish families in the Philippines remained idle, or worse, were confiscated or expropriated
ad absentia by the government or unscrupulous
encargados. Upon the deaths of her Paterno aunts, she and her brothers Simon and Jose inherited the old, beautiful Paterno mansions. Their children were Macaria "Nena" (de Leon) named after Vicente's mother, Paz "Pacita" (Warns, later Gonzalez) who served as senator from 1955 until 1961, Josefina "Pinang" named after Vicente's father Jose Maria (Bayot), Antonio "Tony" and Jose (named after Susana's father Jose Tereso Paterno y Zamora), married to sisters Amanda Abad Santos and Victoria Abad Santos, respectively, Consuelo Alejandra "Chito" (Vazquez later Collantes) and Maria Luisa "Ising" (Vazquez, his brother's marriage to Consuelo Alejandra having been annulled). Madrigal's wealth was equally divided among his seven offspring. He is the grandfather of former Senator
Jamby Madrigal, the daughter of Antonio Madrigal. ==Illegitimacy scandal==