From 2015 to 2020, Prasad was assistant and then associate professor at the
Oregon Health & Science University. He worked at
San Francisco General Hospital. Prasad was a full professor of hematology-oncology at UCSF before he left to work at the FDA in 2025. He is a cancer drug and health policy researcher. He also studies the financial conflicts in drug approvals. In 2015, Prasad published the book
Ending Medical Reversal with physician and academic
Adam Cifu. Prasad hosts the podcast
Plenary Session and blogs at
MedPage Today. Prasad has won several teaching awards, including the 2017 Craig Okada Award for best teacher in the Hematology Oncology Fellowship program, the 2018 faculty mentorship award from the internal medicine residency, the 2019 J. David Bristow award from the graduating medical students, and the 2020 excellence in research and scholarship mentoring as awarded by the internal medicine residents. In the spring of 2020, Prasad published the book
Malignant: How Bad Policy and Bad Evidence Harm People with Cancer.
Views and reception In 2011, Prasad and colleagues published a research letter in the
Archives of Internal Medicine. Charles Bankhead, a senior editor at
MedPageToday, covered the topic, outlining the paper's primary point, which was the high prevalence of research articles demonstrating findings that deviated from the accepted standard of treatment at the time. Separately, "Retraction Watch" reported on Prasad's personal remarks about the paper, saying "For a long time, we were interested by what we believe to be a pervasive problem in modern medicine. Namely, the spread of new technologies and therapies without clear
evidence that they work, which are later (and often after considerable delay) followed by contradictions, which, in turn, after yet another delay, is followed by changes in practice and reimbursement." Matthew Hoffman, writing in 2012 for ''MedPageToday's KevinMD'' covered a paper by Prasad and colleagues on "When to abandon ship" when it comes to failing medical practices and treatments. Hoffman builds on the authors' proposed barriers to market entrance, such as evidence of
effectiveness in large
randomized controlled studies before broad usage, and links them to the insidious aspects of healthcare, such as profit and status. In 2013, Prasad and colleagues addressed the necessity for randomized controlled trials for the
inferior vena cava filter (VCF) despite the intervention's bio-plausibility. The authors suggest that since the intervention has known adverse effects but an uncertain benefit, well-designed studies are necessary to shed light on the intervention's efficacy. The
JAMA Internal Medicine article received widespread media attention, with
Reuters Genevra Pittman interviewing Prasad about his further views on the intervention. According to the interview, Prasad advises against filter placement in all but the most extreme instances owing to a lack of proof and possibility for adverse events. The article was covered in a piece by
The Huffington Post, which highlights a key lesson from the paper: patients should become more involved in their health care decisions rather than assuming a prescribed medication or device is beneficial. Patients may do this by asking their physician pertinent questions, such as what patient outcomes the intervention improved. Additionally, the article discusses the concept of healthcare cost. With growing anxiety about the expense of healthcare, utilizing limited resources on questionable medical practices with a weak evidence base threatens to jeopardize both the healthcare economy and patient health. Additionally, the authors of a
Lancet Oncology editorial remark that "almost 10% of practice reversals occurred in oncology," suggesting that certain fields of medicine may be more susceptible to medical reversals than others. Prasad has criticized other medical skeptics for their choices of topics to tackle, including
homeopathy, as being poor use of their time. Skeptics
David Gorski and
Steven Novella published criticisms of and counter-arguments to Prasad's stance, pointing out the perils of not challenging
alternative medicine during a pandemic.
COVID response In response to the
COVID-19 pandemic, Prasad used social media to promulgate misinformation and take a contrarian stance. He repeatedly attacked public-health leaders and agencies, declaring "These pieces of shit are still lying.… They're still fucking lying.", and asserting "The CDC lied repeatedly, and all the employees at CDC and AAP who told us to cloth mask 2 year olds should be fired for stupidity." Prasad stated that "[We'd] probably be better off as a result of not having the FDA". Bioethicist
Arthur L. Caplan said that Prasad's arguments were specious and ignorant, and science historian
Robert N. Proctor said that Prasad was "trivializing the genuine harms to liberty posed by 1930s fascism". In November 2021, Prasad expressed his opinion that pediatricians should warn parents about risks of COVID immunization such as myocarditis. However, physician Jonathan Howard noted that Prasad was selectively omitting that myocarditis from the vaccine was always mild and that COVID disease itself carried much higher risks, including a worse form of myocarditis which would not be consistent with the tenets of medical
informed consent. In January 2022, the conservative periodical
City Journal published an opinion piece by Prasad in which he attempted to demonstrate that the American public health organizations were not being honest in their response to the COVID-19 pandemic. Writing for
Science-Based Medicine, epidemiologist Lynn Shaffer criticized Prasad's article for the various "mistruths" it contained about face masks as a COVID-19 mitigation measure, for example the unevidenced claim that mask wearing was stunting children's language development. In Shaffer's view Prasad's writing "lean[s] heavily on pushing people's emotional hot buttons" and amounted to a form of fearmongering. Prasad was an early member of the Urgency of Normal, a group that in 2022 campaigned against quarantines and mask mandates in schools during the COVID-19 pandemic. He spoke in support of repealing such mandates in a March 2022 interview.
Engagement with Robert Kennedy's ideas Earlier in 2023, Prasad showed support for the ideas of
Robert Kennedy Jr. However, according to physician
David Gorski, Prasad did not show sufficient understanding of bad faith debate. In November 2023, the levels of kindergarten vaccine exemptions rose to the highest level in years. Prasad mentioned this outcome but did not acknowledge his role in causing this outcome, per physician Jonathan Howard. In 2024, Prasad expressed criticism for the funding decisions of the NIH as well as support for more cluster randomized controlled trials. However, according to physician David Gorski, Prasad again demonstrated insufficient understanding of the limitations of these randomized controlled trials as well as how the NIH's funding decisions work.
FDA Prasad was appointed head of the FDA's
Center for Biologics Evaluation and Research, after the previous head was forced to resign by Kennedy. In late July 2025, Prasad quit after political provocateur
Laura Loomer said he was a "progressive leftist saboteur". Journalist Antonia Hitchens reports that Prasad had been attempting to place a hold on a muscular-dystrophy drug for safety reasons, but that it would have cost
Sarepta Therapeutics, the drug's manufacturer, millions of dollars. A Trump Administration official told Antonia Hitchens that "the consensus among political leadership" was that the attack on Prasad "was a directed assault by corporate forces." In explaining the absence, FDA Commissioner Marty Makary stated that "He [Prasad] saw some media headlines and didn't want to be a distraction", and that Prasad was convinced to return. On August 29, 2025, Prasad demanded of
YouTube that six of his critic Jonathan Howard's videos be taken down. Subsequently, Howard's entire channel, a record of the medical positions of various doctors and administrators, was removed. Prasad has been the subject of numerous internal complaints at the FDA, including "
retaliation against subordinates and verbally berating staff." In February 2026, the FDA refused to review
Moderna's application for an
mRNA flu vaccine.
Stat and
The Wall Street Journal reported that Prasad had single-handedly made the decision, overruling scientists at the agency. In November 2025 Prasad sent a 3,000 word memo to FDA staff saying it would change the process for approving vaccines, and claiming without evidence that ten children had died as a result of Covid vaccination. The memo said that the figure came from an "initial analysis" of 96 deaths, but did not offer further details. Prasad characterized the claim as a "profound revelation". Former deputy director CBER Phil Krause, who was mentioned approvingly in Prasad's memo, said that while he supported Prasad's call for gathering more data on vaccines, he considered the change to the vaccine approval process "destructive" of what "has been an excellent system", and called for "radical transparency" and for Prasad to publish evidence for his claims about fatalities.
Paul Offit said the claims were both "irresponsible" and "dangerous";
Peter Marks said the memo's content was taken from the
anti-vaccine playbook. To date, no evidence the COVID-19 vaccine killed children has been released by the FDA. In March 2026,
The Wall Street Journal reported that Prasad would leave his position the following month. == Personal life ==