Film Colosimo has had success in film and television in Australia and abroad. He debuted in the coming-of-age story
Moving Out in 1983 and featured in 1984's
Street Hero. Other credits include the cult movie
Chopper (2000), in which he played Melbourne drug dealer Neville Bartos opposite
Eric Bana;
The Wog Boy (2000);
Lantana (2001);
Walking on Water (2002);
The Nugget (2002);
Take Away (2003); and
Opal Dream (2006). In 2010, Colosimo starred in the sequel
Wog Boy 2: Kings of Mykonos. In 2011 he starred in the film
Face to Face, and in 2012 he starred in Starz "Spartacus" Season 4, portraying a pirate leader. In 2013 he appeared as a coffee shop owner in
The Great Gatsby alongside
Leonardo DiCaprio. He appeared in the 2018 film
The Second.
Television Despite several movie roles and guest roles in
A Country Practice (1994),
Good Guys Bad Guys (1997) and
Stingers (2002), it was not until his performance as Joe Sabatini in
Something in the Air in 2001 and 2002 that resulted in wider exposure. In 2003, he starred in the telemovie,
After the Deluge. In 2003 and 2004, he played Dr. Rex Mariani in
The Secret Life of Us. followed by roles in
MDA (2005),
Two Twisted (2006) and
City Homicide (2007). His American credits include popular shows such as
The Practice (2004) and
Without a Trace (2003). 2008 was a busy year for Colosimo. He portrayed Melbourne gangland figure
Alphonse Gangitano in the Channel 9 series
Underbelly (in a guest role); Channel Ten's telemovie
Emerald Falls and Channel Nine's
Scorched. He also appeared in
Top Gear Australia's "Star in a bog-standard car" section in the first episode. In early 2009, Colosimo appeared in
Carla Cametti PD, a six-part series that aired on
SBS. In 2010, he had the leading male role in the tele-movie,
Wicked Love: The Maria Korp Story about the
Maria Korp case. In 2012 he and his ancestors featured in the SBS show,
Who Do You Think You Are? He reprising his role of Alphonse Gangitano in the Underbelly sequel/spin-off series Fat Tony & Co. in 2013, featuring in one episode. In May 2022, Colosimo appeared as a contestant on the sixth season of
The Celebrity Apprentice Australia.
Other endeavours Colosimo was part-owner of a cafe in
Northcote, Espresso Alley, with Vince Mazzone. He also sampled his voice on "Snitch" by
Vanessa Amorosi in on her 2009 album
Hazardous (album) ==Personal life==