SR 145 begins at an intersection with SR 10 (Iron Bridge Road) in Chesterfield. The state highway heads east as two-lane undivided Centralia Road toward the hamlet of
Centralia, where the highway has a grade crossing of
CSX's
North End Subdivision. Just east of the railroad crossing, SR 145 meets the northern end of
SR 144 (Chester Road). SR 145 turns north onto Chester Road, which is a four-lane
divided highway from just south of the SR 144–SR 145 intersection to north of the state highway's
diamond interchange with the
SR 288 freeway. North of the freeway, SR 145 closely parallels CSX's
Bellwood Subdivision rail line northeast to Bellwood. There, the highway veers east and makes a 90-degree turn north at Perrymont Road. SR 145 veers east again and reaches its northern terminus at US 1 and US 301 (Jefferson Davis Highway). ==History==