Critics lauded Calamy's performances in the short films ''Ce qu'il restera de nous
, directed by Vincent Macaigne, and Un monde sans femmes'', directed by Guillaume Brac, for which she received the Jeanine Bazin prize at the
Festival Entrevues de Belfort. Her performance in Cécile Ducrocq's short film
Back Alley (
La contre-allée), which was first screened during
International Critics' Week at the
Cannes Film Festival, earned her a
Special Jury Prize for Acting at the
Sundance Film Festival. Calamy initially appeared in feature films in supporting roles. She became known to a wider audience for her portrayal of Noémie in the television series
Call My Agent! (Dix pour cent). In 2018, she was nominated for the
César Award for Best Supporting Actress for her role in
Léa Mysius's
Ava. The same year, she received the
Molière Award for Best Actress in a Private Theatre Show for her performance in
Marivaux's ''
The Game of Love and Chance (Le jeu de l'amour et du hasard)'', directed by
Catherine Hiegel at the
Théâtre de la Porte-Saint-Martin. In 2020, Calamy starred as Antoinette in Caroline Vignal's
My Donkey, My Lover & I (Antoinette dans les Cevennes), an unexpected box-office success in France, and received positive reviews from critics. She won the
César Award for Best Actress for her role in the film. In 2021, Calamy won the Orizzonti Award for Best Actress at the
78th Venice International Film Festival for her starring role in Éric Gravel's
Full Time. In October 2025, Calamy joined the cast of
Nicole Garcia's upcoming film
Milo. == Personal life ==