Vonitsa is built near the site of ancient
Anactorium, an important city of
Acarnania, founded by the
Corinthians in 630 BC. Like the other cities of Acarnania, it went into decline when the Romans founded
Nicopolis on the other side of the
Ambracian Gulf after the
Battle of Actium, and forced its inhabitants to move to that city. Modern Vonitsa was founded during the
Byzantine era, and it was the last stronghold of the
Despotate of Epirus before being conquered by the
Ottomans in 1479.{{cite web |title = Despotate of Epirus |date = 10 August 2020 |website =
World History Encyclopedia |url = https://www.worldhistory.org/Despotate_of_Epirus/ |access-date = 8 November 2025 by the Venetians in November 1717 On 18 October 1862 the
insurrection that later spread to
Athens and lead to the overthrow of
King Otto of Greece, started in Vonitsa. ==Population==