Main •
Dick Dastardly the Third and Muttley (voiced by
Peter Woodward and
Billy West): In this modern series, Dick Dastardly is still up to his usual trickery and cheating activities, though is now often badgered into either being nice or not cheating by
Peter Perfect. Unlike before, his appearance is predominantly purple in color instead of blue, red and purple. Muttley, however, has undergone virtually no changes aside from his outward appearance, still either snickering or grumbling. In "Mother Drives Best", it is revealed that Dick Dastardly is actually the son of Dick Dastardly the Second from the original
Wacky Races series, and Delilah Dastardly, who taught her own son how to cheat. In "Grandfather Knows Dast", his grandfather is revealed to be Dick Dastardly the First from
Dastardly and Muttley in Their Flying Machines. •
Penelope Pitstop (voiced by
Nicole Parker): Another original character, Penelope Pitstop has undergone the most changes from the original, both in appearance and outlook. While more assertive and much less of a damsel in distress than the original, she is still often the goody-two-shoes of the group and still talks like a
Southern belle. Like before, her appearance is predominantly pink with hearts. •
Peter Perfect (voiced by
Diedrich Bader): Like Dastardly and Muttley, largely unchanged from the original, although he is a bit more taunting of Dastardly and his intelligence has been drastically reduced. His appearance is predominantly orange and red. •
Tiny and Bella – the Gruesome Twosome (voiced by
Billy West and
Tom Kenny) are the other characters from the original series, and are the closest to their original versions in almost every respect. •
Ignatius Quinton "I. Q." Ickly (voiced by
Jill Talley): Often called a "walking encyclopaedia" by Dastardly, this new character has underdeveloped social skills. Like Professor Pat Pending before him, he is a genius inventor who uses gadgets throughout the race. Only 10 years old, he cannot drive legally and uses a car with onboard
artificial intelligence that frequently misunderstands his verbal commands.
Secondary Racers •
Pandora Pitstop (voiced by
Nicole Parker): A new character. Penelope's
twin sister and frequent guest Racer. She is similar to Penelope, except her outfit is predominantly purple and is often meaner and more underhanded than even Dastardly. She often allies with Dastardly, but usually for her own ends. •
Captain Dash, Polly, Bugsy, Bluebeard and Davey Bones (voiced by
Billy West and
Tom Kenny): A gang of pirates that often steal gigs from Dastardly. They are similar to the Anthill Mob from the original Wacky Races.
Non-racers •
Brick Crashman (voiced by
Christopher Judge): A former racer and the enthusiastic announcer for the Wacky Races. He often changes his appearance or character to match the location of the episode's racecourse, and is at a loss as to what to do when there is no actual race happening in an episode. •
Pearl Tricia "P. T." Barnstorm (voiced by
Jill Talley): The owner and sponsor for the Wacky Races. A diminutive old woman with a southern drawl who claims to be concerned with the racer's well-being, but in truth only cares about their profitability.
Guest stars •
Hooded Claw (voiced by Tom Kenny impersonating
Paul Lynde) •
Huckleberry Hound (voiced by Billy West): a guest racer and Peter Perfect's stunt double •
Snagglepuss (voiced by Billy West and Tom Kenny) •
Hong Kong Phooey (voiced by
Phil LaMarr) •
Quick Draw McGraw (voiced by Billy West) •
Touché Turtle (voiced by Billy West): a guest racer •
Ricochet Rabbit (voiced by Tom Kenny): a guest racer. • The Dalton Brothers • Dinky Dalton (voiced by Christopher Judge) • Finky Dalton (voiced by Tom Kenny) • Pinky Dalton (voiced by Diedrich Bader) • Stinky Dalton (voiced by Billy West) •
Winsome Witch (voiced by Nicole Parker): a guest racer. •
Paw and Maw Rugg (voiced by Billy West and Jill Talley) •
Mildew Wolf •
Magilla Gorilla •
Scooby-Doo •
Scrappy-Doo (voiced by Tom Kenny): Scooby-Doo's nephew •
Mr. Jinks (voiced by Billy West) •
Jabberjaw (voiced by Billy West) •
Chief (voiced by Billy West) •
Top Cat •
Benny the Ball == Episodes ==