Cheesman moved to
Chicago in 1854 to start a pharmacy business with William Henry and Edward Talbot Cheesman, his older brothers. His brothers came to Denver in 1859 and opened a pharmacy store, but they were not very successful, so Cheesman came to Denver in 1861 and took over the business. He added bottled water and liquor to the store's merchandise. In 1868 he,
John Evans and
David H. Moffat began work to build the
Denver Pacific Railroad to
Cheyenne, Wyoming. Cheesman was president of the railroad for several years. He planned for the construction of the
Union Station, and he was active in the building of the Denver Boulder Valley Railroad and South Park Road. The railroad helped Denver become a major city. He also was a director of the
Denver, Northern, and Pacific Railway Company. Cheesman determined the location of the court house by purchasing the land and selling it to the city for an affordable price. The court house otherwise would have been located further from the center of the city. He was an organizer of the International Trust Company and served as a member of its executive committee for more than 15 years, and he was a member of the Denver Real Estate Exchange. He bought real estate throughout the years, established financial institutions, and helped develop mines. and
Cheesman Reservoir In 1870, he became a principal in a company to provide water to Denver and served on the board of directors. Two water plants were consolidated into the monopolistic
Denver Union Water Company in 1894, and he, David Moffat, and Thomas Hayden owned the controlling stock. Cheesman became president of the company that grew to a $25 million organization. He built dams, reservoirs, and filtration and distribution systems.
Cheesman Dam and
Cheesman Reservoir are named for him. ==Personal life==