Guglielmone began his career in Uruguay, making his debut for
Nacional de Montevideo in 1999. However, after just a year in France, he returned to Uruguay, where he played for
Danubio during the first half of 2004. He joined
Pachuca for the 2004 Apertura, finishing the season with three goals in 11 games played, 6 starts. In 2007, Guglielmone joined
Azerbaijan Premier League side
Inter Baku, becoming the first Latin American to play for the club. Guglielmone spent two season with Inter and was the top goalscorer during the
2008–09 season. For his third season in Azerbaijan, Guglielmone moved to Baku rivals,
Neftchi Baku. After leaving Neftchi Baku in the summer of 2010, he joined
Club Guaraní of the
Paraguayan Primera División in July 2010. In July 2011, after one season back at Wanderers, Guglielmone was released. Five months late, on 21 December 2011, Guglielmone joined Brazilian side
Pelotas. On 31 March 2012, Guglielmone received a red card for shoving teammate Douglas Silva twice in the face in a
Campeonato Gaúcho match against
Caxias. After leaving Pelotas, Guglielmone signed with
Beijing BIT in the
Chinese Jia League. ==International career==