Orenstein began working for the CDC's Immunization Program in 1982. He has also served as a consultant to the
World Health Organization and the
Pan American Health Organization, and was formerly the Assistant Surgeon General of the
United States Public Health Service, as well as the CDC liaison member to the National Vaccine Advisory Committee for over 14 years. He has served on the Board of Directors of Vaccinate Your Family for over two decades, offering his scientific and medical expertise. He has also co-authored the textbook
Vaccines along with
Paul Offit and
Stanley A. Plotkin. He is currently a professor of infectious diseases at
Emory University, a post he was originally appointed to in March 2004 and then held until October 2008, after which he became affiliated with the
Bill and Melinda Gates Foundation, where he served as deputy director of immunization programs before returning to Emory in September 2011. ==Selected publications==