Philip was determined to reverse the Susa treaty and replaced Córdoba with
Spinola, a native of
Genoa and former commander in the
Spanish Netherlands. Nevers unwisely led 2,500 troops in an attack on Spanish-held
Cremona, which his Venetian allies refused to support. Combined with the withdrawal of the main French army, this left him vulnerable to a counter-offensive. Richelieu positioned 18,000 troops on the Savoyard frontier to deter Imperial intervention, but Ferdinand viewed opposing the French in Italy as a higher priority than supporting Spain against the Dutch. The June 1629
Treaty of Lübeck that ended his war with
Denmark-Norway allowed Ferdinand to send 30,000 troops from Germany under the Mantuan exile
Ramboldo, Count of Collalto. Hoping to overwhelm Casale and prevent interference by Charles Emmanuel, Spinola sought to expand his existing force of 16,000 with another 12,000 mercenaries and 6,000 reinforcements from Naples. He also invoked treaties with
Tuscany and
Parma to supply 4,000 and 2,000 men respectively but despite its size, his army contained many poor quality troops. Although
Ferdinando II undertook to provide 6,000 men for two years along with use of the Tuscan navy, he ultimately avoided doing so. The siege of Casale and its French garrison of 2,500 resumed in June; in late October, Collalto dispersed a Venetian force of 7,000 before moving onto Mantua, held by a garrison of 4,000. Neither siege made much progress; Mantua was protected by two artificial lakes which made it difficult to position siege artillery and Collalto withdrew after an unsuccessful assault in late November. As Collalto fell ill, he left command to his deputies
Gallas and
Aldringen. Casale continued to hold out, while the Spanish were unable to pay or support so many men and large numbers were lost to desertion and disease. Charles Emmanuel switched sides again and in December joined Spinola at Casale with 6,500 men, leaving 12,500 to guard
Piedmont and another 6,000 in Savoy, while Tuscany, Parma and other Spanish allies provided additional recruits and money. A French army of 18,000 under
Henri II de Montmorency overran Savoy, before invading Piedmont in February 1630; on 10 July, he defeated a combined Savoyard-Spanish force at
Avigliana. Both sides were badly affected by an outbreak of
bubonic plague, allegedly brought from Germany by French and Imperial soldiers. The "worst mortality crisis to affect Italy during the
early modern period", approximately 35% of the population of Northern Italy died between 1629 and 1631. The increasing brutality of the war led to a number of massacres, most notably at
Ostiglia in April 1630, when local bandits, or "Formigotti", cut off an Imperial foraging party and assaulted the nearby garrison in Ostiglia. After its defeat, Imperial troops retaliated by attacking the civilian population, with contemporary sources estimating the number killed as around 600, including women and children. When the siege of Mantua resumed in May 1630, its defenders had been reduced by disease to under 2,000, while a hastily assembled and poorly equipped relief force of 17,500 Venetian auxiliaries was routed by the Imperials at
Villabuona. With the mutinous and unpaid garrison down to only 700 effectives, it surrendered to Gallas and Aldringen on 18 July; the sack that followed reportedly produced booty worth over 18 million
ducats. Plague and the sack combined to reduce the population of Mantua by over 70% between 1628 and 1631 and it took decades to recover. Despite this, the retention of Casale meant Nevers' cause remained alive; on 26 July, Charles Emmanuel died and was succeeded by his son
Victor Amadeus, who was married to
Christine of France, Louis XIII's younger sister. On 6 August, Montmorency defeated the Savoyards at
Carignano; losses from disease and desertion left him too weak to relieve Casale, but reinforcements under
Charles de Schomberg reached the fortress in early October. The siege works were flooded by heavy rain while the besiegers had been reduced by plague to under 4,000, their casualties including Spinola; on 29 October, the Spanish finally withdrew and the two sides agreed a truce, negotiated by the papal representative Mazarin. ==Peace and its Aftermath==