While attending the seminary, he was ordained as pastor of Central Baptist Church in 1951 and served until 1957. From September 1957 to 1961, Wiersbe served as Director of The Literature Division for
Youth for Christ International. From 1961 to 1971 he pastored Calvary Baptist Church of
Covington, Kentucky south of
Cincinnati, Ohio. The church grew from a church seating a congregation of eight hundred to build a new church seating of two thousand. This church drew members from the Ohio, Indiana and Kentucky Tri-state Area. His Sunday sermons were broadcast as the
Calvary Hour on a local Cincinnati radio station. From 1971 to 1978, Wiersbe pastored Chicago's
Moody Church, named for 19th century evangelist
Dwight L. Moody. While at Moody Church, he continued in radio ministry as speaker on the
Songs in the Night nationally syndicated radio program that moved to Moody Church in 1968. Between August 1979 and March 1982, he wrote bi-weekly for
Christianity Today as "Eutychus X". During the same time frame between 1978 and 1982, Wiersbe taught
practical theology classes at
Trinity Evangelical Divinity School in
Deerfield, Illinois and wrote the course material and taught "Imagination and the Quest for Biblical Preaching", a
Doctor of Ministry course at Trinity and Dallas Seminary. While pastoring in Chicago, Wiersbe served on the board of Slavic Gospel Association (SGA) from 1971 to 1983, ten of those years he served as chairman of the board. From 1980 to 1992, he went to work for the
Back to the Bible radio broadcast and succeeded
Theodore Epp as general director the last six years of his time there. Most of this information is available through Warren Wiersbe's autobiography
Be Myself: Memoirs of a Bridgebuilder. ==Personal life and death==