En route to a
football game, Carly Jones, her delinquent twin brother Nick, her boyfriend Wade Felton and their friends – Dalton Chapman, Paige Edwards and Blake Johnson – set up camp for the night in a wooded area. A stranger in a
pickup truck arrives, then leaves after Nick damages one of the truck's headlights. The next day, Wade discovers his car's
fan belt has been severed; a local named Lester offers to drive Wade and Carly to the nearby town of Ambrose while the rest of the group head to the game. In Ambrose, which is virtually a
ghost town,
mechanic Bo Sinclair offers to sell Carly and Wade a fan belt and drive them back to their car after he finishes attending a
funeral. While waiting, they visit the central feature of the town – "Trudy's House of Wax", a wax museum-like
tourist trap which is itself, like everything inside, made of wax. They follow Bo to his house to get the fan belt; Carly waits in his truck while Wade goes inside to use the bathroom. Wade is soon ambushed and abducted by Bo's twin brother Vincent, who wears a wax-made mask to cover his facial
disfigurement from when they were once
conjoined. When Carly notices Bo's truck has a broken headlight and realizes it was he who visited the campsite, she flees with Bo in pursuit, ultimately being caught and taken to the local
filling station's cellar. Realizing they will not arrive at the game in time, Paige and Blake return to the campsite while Nick and Dalton arrive in Ambrose to look for Carly and Wade. When Carly attempts to call for help, Bo cuts off the tip of her
index finger. She eventually gets Nick's attention as he fends off Bo and rescues her, while Dalton finds Wade as part of the House of Wax, restrained in coated wax. Dalton tries to free him by peeling off the wax from his face, inadvertently removing his skin in the process. Vincent then ambushes Dalton and slashes off more of Wade's face, causing him to instantly die of shock, before decapitating Dalton. While searching the town for help, the Joneses realize that the
wax figures, both in the House of Wax and placed around Ambrose to make it appear populated, are actually the wax-coated corpses of its inhabitants and visitors lured there. Vincent had been attempting to continue the wax sculpting work of his mother and the House of Wax's creator, Trudy Sinclair, following her death, but Bo began manipulating him into making more realistic figures out of their victims. At the campsite, Vincent murders Blake and chases Paige into an abandoned sugar mill, where he does the same to her using a metal
pipe. Vincent encounters the Joneses in the House of Wax's basement as Nick unintentionally incites a building-wide inferno. Upstairs, Nick battles Bo and is stabbed in the leg before Carly beats Bo to death with a
baseball bat. A vengeful Vincent chases Carly to the top floor where she tries to reason with him but then fatally stabs him with Nick's help. The deceased Vincent ends up on top of Bo's corpse, while the Joneses escape as the House of Wax melts to the ground. The next morning, local authorities, having seen the fire’s smoke, arrive and report about how Ambrose had been abandoned for the past decade ever since the local sugar mill went out of business. As the Joneses are driven away in an
ambulance, one of the officials is told that the Sinclair family had a third son. The ambulance passes by Lester, who waves goodbye to the siblings while smiling. == Cast ==