Weberbauerocereus cuzcoensis grows like a tree with richly branched, sprawling, grey-green shoots with a diameter of and reaches heights of 3 to 4 meters with 10 to 14 ribs that are high and extremely blunt. The
areoles on the stem are oval to circular and covered with white wool and strong, yellow to brownish spines. There are three to eight, hardly stinging central spines are and 10 to 14 radial spines long. The lowest radial spines are the longest. The somewhat radially symmetrical, unpleasantly scented flowers open at night. They are long. Its light green flower tube is covered with brownish hairs. The bracts are white at their base and turn pale pink towards the tip. The fruits are dark green, long and reach a diameter of . ==Distribution==