Wenona is an unincorporated community and census-designated place (CDP) in Crisp County, Georgia, United States. It is on U.S. Route 41 where it is joined by Georgia State Route 33, 4 miles (6 km) south of Cordele, the county seat, and 5 miles (8 km) north of Arabi. Interstate 75 forms the eastern border of the CDP, with access from Exit 97.