The Wentworth-Gardner House is a historic mid-Georgian house built in 1760 and located at 50 Mechanic Street in Portsmouth, New Hampshire, United States. The house is operated as a museum by the Wentworth-Gardner Historic House Association. It is one of the finest extant examples of high-style Georgian architecture in New England, and played a role in the architectural preservation movement of the early 20th century. It was declared a National Historic Landmark in 1968.