West Virginia Route 10 is a north–south route from Cabell County to Mercer County in the western and southern regions of West Virginia. Mostly a two-lane, winding highway with no shoulders, Route 10 is considered to be one of substandard design when compared to modern standards. Nevertheless, it serves as a major arterial highway in the state, carrying a substantial amount of traffic volume. Tractor-trailers have a particularly difficult time negotiating many of the route's sharp, hairpin curves.