European settlement in the Wetheron area began in 1845, when William Humphreys and Henry Arthur Herbert took up a run of
crown land on the south bank of the
Burnett River. The estimated was about from
Gayndah and from
Maryborough and was known as Wetheron Head Station. This was transferred to William Humphreys solely in 1851, along with the
Ginoondam run. Chinese labour was employed at Wetheron during Humphreys tenure. When Humphreys advertised the Wetheron runs for sale in 1857 the head station was described as consisting "of a comfortable
verandah house,
shingled, and containing 4 rooms and pantry, a kitchen, store, and meat store, overseer's house, shingled;
woolshed, fitted with yards, shearer's house, shingled; two labourer's huts; a good two rail horse paddock; small cultivation paddock (3 rail); garden, stockyard, milking yard, pigsties, etc. There are seven out stations, with substantial huts, and yards or
hurdles at each of them." The run consisted of Wetheron Head Station, Ginoondam, Wateranga and Gooroolballam stations. The co-operative groups of
Bon Accord,
Byrnestown and Resolute settled on sites on a Wetheron run resumption in 1894. The Wetheron Run had been reduced to by 1901. In 1905, more parts of Wetheron were being opened up as agricultural farms and unconditional selections, and in 1908 the leasehold expired. The
Mungar Junction to Monto Branch Railway was opened to the town of Wetheron on 21 December 1905. At that time, the town consisted of a newly built hotel, kept by Mr. A. A. Morgan, and a fruit shop and general store. The
Mungar Junction to Monto railway line opened between Wetheron to Gayndah on 16 December 1907. Wetheron State School opened on 24 January 1916. It closed on 31 December 1963. It was on John Street (). Mrs Helen Gray donated a quarter-acre of land and a parish hall was erected by George James Bellert. The hall was officially opened on 5 May 1926. St John's Anglican Church was dedicated on 11 December 1927 by Venerable William Powning Glover, Archdeacon of Toowoomba. It is now closed. Sefton Provisional School opened in 1925 and closed in 1926. In 2012, the railway line was officially closed. == Demographics ==