The
Manistee River flows westward through the upper part of Wexford County. The county terrain consists of low rolling hills, largely tree-covered. The terrain slopes to the west, with its highest point,
Briar Hill in Manistee National Forest at . According to the US Census Bureau, the county has a total area of 575.46 sqmi (1,490 km2), of which 565.00 sqmi (1,463 km2) is land and 10.46 sqmi (27.1 km2) (1.8%) is water.
Adjacent counties •
Grand Traverse County – north •
Kalkaska County – northeast •
Missaukee County – east •
Osceola County – southeast •
Lake County – southwest •
Manistee County – west •
Benzie County – northwest
Protected areas • Brandy Brook Waterfowl Area •
Manistee National Forest (part) •
Mitchell State Park Lakes Source: • Hodenpyl Dam Pond •
Lake Cadillac • Lake Gitchegumee •
Lake Mitchell • Long Lake • Round Lake (part)
Major highways • is a north–south highway that runs in the east of the county. Much of the highway within Wexford County is a freeway, including bypasses of
Cadillac and
Manton. South of Wexford County, the highway can be used to access
Reed City,
Big Rapids,
Grand Rapids, and
Kalamazoo. North of Wexford County, the highway, as a two-lane road, can be used to access
Kalkaska and
Petoskey. • is a
business route serving downtown Cadillac. The route was created in 2001 with the completion of the US 131 freeway on the east side of Cadillac. • is a business route serving downtown Manton. The route was created in 2003 with the completion of the US 131 freeway on the east side of Manton. • is a north–south route in the west of the county. The highway runs through the villages of
Mesick and
Buckley. South of Wexford County, the highway can be used to access
Baldwin,
White Cloud, and
Newaygo. North of Wexford County, the highway can be used to access
Traverse City. • is an east–west highway in the northeast of the county. The route begins in Manton, and continues east into Missaukee County, where it can be used to access
Lake City. Prior to 2007, the highway continued west from Manton to M-37 near Mesick. • is an east–west route that runs in the south of the county. The highway passes to the south and east of Cadillac, concurrent at points with US 131 and M-115. West of Wexford County, the highway can be used to access
Manistee. East of Wexford County, the highway can be used to access Lake City and
Houghton Lake. • is a diagonal northwest–southeast highway. The highway passes through the village of Mesick and passes southwest of Cadillac. Northwest of Wexford County, the highway can be used to access
Copemish and
Frankfort. Southeast of Wexford County, the highway can be used to access
Clare. ==Communities==