The song first saw increased popularity after featuring in the 1999 film
Fight Club, in which it plays during the final scene. On April 13, 2004,
NASA used "Where Is My Mind?" to wake up the team working on the
Spirit Mars rover, in honor of its software transplant. Its popularity led to the Pixies' live performance of the song at
Coachella in 2004 to be heavily
pirated online. In March 2021, the song began being used as the
entrance music for professional wrestlers
Orange Cassidy and
Best Friends after it was licensed by
All Elite Wrestling: it was replaced with the
Jefferson Starship song "
Jane" in 2022 but was restored in 2024. In 2023, the song's opening lyric inadvertently caused certain
Android phones to turn off set alarms. The song featured in the
Criminal Minds episode "Sex, Birth, Death", which aired on November 29, 2006, while a xylophone-only cover of the song was used in the episode "The Lesson", which aired on December 5, 2012. A cover version by
Allison Scagliotti appears in the
Warehouse 13 episode "Don't Hate the Player", which aired on August 15, 2011. An all-
kazoo cover of the song was used in
The Tick episode "Where's My Mind", which aired on August 25, 2017. The original version of the song also featured in the films
Gaz Bar Blues (2003),
Mr. Nobody (2009),
Knock Knock (2015), and the teaser trailer for
Thunderbolts* (2025). Cover versions of the song have also widely been used in film: those by
Yoav and
Storm Large feature in
Sucker Punch (2011) and
Big Ass Spider! (2013), respectively. Safari Riot and Grayson Sanders’ version of the song is used in
Malignant (2021). The song's piano cover by
Maxence Cyrin has seen the widest use: it has been featured in the television series
The Leftovers (alongside the original version) and
Mr. Robot, in the film ''
It's Kind of a Funny Story (2010), and in the "Man Behind The Treasure" promotional material for the video game Uncharted 4: A Thief's End'' (2016). The song's widespread use in film and television has been criticized as a narrative cliché for informing audiences that characters suffer from
multiple personalities or cannot distinguish reality. ==Weekly charts==