Main •
André de Vanny as
Toby Johnson, a normal teenager and the main protagonist who studies in Sandy Bay High School. He was one of two students involved in an accident following an experiment on a prehistoric rock, which caused him to become a genius. His best friends are Russell Skinner and Dina Demeris. He is also in love with Bianca, a pretty girl in his class. •
Bridget Neval as
Elizabeth Hawke, the main antagonist) was also involved in the accident that turned Toby into a genius. Unlike Toby, she wants to use her newfound genius to take over the school. She dislikes everybody except Toby, whom she is secretly in love with. She is jealous and demonstrates that she will go to any length to get what she wants. •
Benjamin Schmideg as
Russell "Russ" Skinner, Toby's best friend. He likes to skateboard and eat pizza. While not being too clever, he is a loyal and brave friend. •
Saskia Burmeister as
Dina Demiris, a good friend to Toby and Russ. She is smart, good looking, boys get on her nerves sometimes and she hates Elizabeth. She goes to Hong Kong in Series 2 and is replaced by Sasha. •
Emma Leonard as
Verity McGuire, Elizabeth's best friend since Primary School who often assists Elizabeth in her schemes. While she knows Elizabeth goes too far, she does not have the confidence to speak up. •
Brook Sykes as
Garth King, the dimwitted school bully. He is often in cahoots with Elizabeth and acts as her spy. He is always up for a fight, especially if it involves Russ. •
Robert van Mackelenberg as
Professor Carl Tesslar, the
physics professor at Sandy Bay High School. •
Geneviève Picot as
Principal Alexa Vyner, Sandy Bay High School's principal. •
Greta Larkins as
Sacha Johnson, Toby's cousin, who moves to Sandy Bay in Series 2, the last Series of Wicked Science, before it was finished after the last episode.
Recurring •
Cleopatra Coleman as Emma Hellman (8 episodes)
Guests •
Alexander Cappelli as Shannon •
Benjamin McNair as Earl Hanley •
Bernard Curry as The Director •
Jeremy Stanford as Max •
Jessica Tovey as Nadine Sterling •
Louise Siversen as Elsa Bailey •
Michelle Vergara Moore as Miss Buckingham •
Nicholas Bell as Virgil ==Episodes==