Smith Cabin Run is a tributary of North Branch Mehoopany Creek in Sullivan County, Pennsylvania, in the United States. It is approximately 1.6 miles (2.6 km) long and flows through Colley Township. The watershed of the stream has an area of 1.45 square miles (3.8 km2). The stream has a high gradient and flows primarily through forested land. It has an unnamed pond at its headwaters and a 20-foot (6.1 m) waterfall on an unnamed tributary.