TRPM

The relative permeability of calcium and magnesium varies widely among TRPM channels. • TRPM4 and TRPM5 are impermeable to calcium. • TRPM3, TRPM6 and TRPM7 are highly permeable to both calcium and magnesium. The mechanism of activation also varies greatly among TRPM channels. • TRPM2 is activated by ADP-ribose adenosine 5'-diphosphoribose and functions as a sensor of redox status in cells. • TRPM4 and TRPM5 are activated by intracellular calcium. • TRPM8 can be activated by low temperatures, menthol, eucalyptol and icilin. ==Functions==

Among the functional responsibilities of the TRPM channels are: • regulation of calcium oscillations after T cell activation and prevention of cardiac conduction disorders (TRPM4). • modulation of insulin secretion and sensory transduction in taste cells (TRPM5). • cold sensation (TRPM8). • heat sensation and inflammatory pain (TRPM3). • regulation of magnesium reabsorption in the kidneys and absorption in the intestines (TRPM6). • regulation of cell adhesion (TRPM7). ==Genes==

• TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8 ==References==