McDonough founded an architectural practice in
New York City in 1981. He moved his practice, William McDonough + Partners, to
Charlottesville, Virginia in 1994 when he accepted the position of the dean of the School of Architecture at the
University of Virginia. He served as dean until 1999 and has since been a professor of business administration and an alumni research professor. McDonough centers his work on cradle-to-cradle design, a philosophy defined in his firm's 2002 book,
Cradle to Cradle: Remaking the Way We Make Things. The goal of cradle-to-cradle design is to shift thinking from doing "less bad" to being "more good". In 2002, he was the subject in
The Next Industrial Revolution, a documentary directed by Christopher Bedford and
Shelley Morhaim. McDonough's architecture firm's designs are mostly categorized as green architecture or sustainable architecture, often using solar and passive energy efficiency techniques. This type of architecture is not known for its distinctive visual style but instead for minimizing the negative environmental impact of a building. McDonough says he aspires to design something like a tree, something that creates good, like oxygen, rather than minimizing negative impact. McDonough co-founded the
Make It Right Foundation with
Brad Pitt to rebuild the
Lower Ninth Ward in New Orleans in 2007. In 2008, McDonough was a senior advisor and Venture Partner at
VantagePoint Capital Partners, one of the largest venture capital investors in
clean technology. On May 20, 2010, at Google's
Googleplex, McDonough announced the launch of the Green Products Innovation Institute, a non-profit public/private collaboration which was later renamed the Cradle to Cradle Products Innovation Institute. Executives from Google, Walmart, YouTube, Shaw Inc., and Herman Miller Inc. joined McDonough for the announcement. Located in Charlottesville, Virginia, the institute builds on the 2008 California state law establishing the nation's first
green chemistry program. At the January 2014
World Economic Forum (WEF) annual meeting in
Davos, Switzerland, McDonough led a workshop for CEOs that was centered around sustainable design, with an added focus on cradle-to-cradle, the upcycle, and the
circular economy. Before the meeting, he participated in the organizing process in
Geneva, when the WEF partnered with the
United Nations to review climate change. McDonough was appointed chair of the forum's Meta-Council on Circular Economy in July 2014. He addressed the Arctic Circle China Forum in
Shanghai in May 2019. He is a senior fellow of the
Design Futures Council. == Projects ==