Spofford was ordained deacon in November 1944 and priest on June 23, 1945 at the Church of the Good Shepherd in
Boston by Bishop
William Appleton Lawrence of Western Massachusetts. He had married Pauline Lindell Fawcett on September 9, 1944 and together had five children. She died in 2008. He initially served as minister-in-charge of the Church of the Good Shepherd in
Boston from 1944 until 1946 and as acting minister at
Grace Church in
Jamaica, Queens in 1946. He then served as Executive Secretary of the Episcopal League for Social Action between 1946 and 1949 and as rector of St Thomas Church in
Detroit from 1947 until 1950. In 1950 he became the Assistant Director of the Western Extension Center at the Town-Country Church Institute in
Weiser, Idaho and then became its director in 1953. He held the latter post until 1956 when he was appointed chief of chaplain at the
Massachusetts General Hospital. Between 1960 and 1968 he held the post of Dean of
St Michael's Cathedral in
Boise, Idaho. ==Bishop==