•
William Colle (fl. 1397–1414), MP for Leominster in 1397 •
William Cole (burgess) (1691–1729), planter and member of the House of Burgesses, grandson of William Cole (immigrant) •
William Cole (councillor) (1638–1694), planter and member of the Virginia Governor's Council, son of William Cole (immigrant) •
William Cole (planter) (c.1571–1653), English planter, politician and soldier in Ireland •
William Cole (immigrant) (c. 1598-before 1664), English planter, politician and family founder in Virginia •
William Cole, 1st Earl of Enniskillen (1736–1803), Irish peer and politician •
William Cole, 3rd Earl of Enniskillen (1807–1886), known as Viscount Cole •
William Cole (Australian politician) (1858–1938), South Australian House of Assembly •
William Cole (public servant) (1926–2019), Australian •
William Clay Cole (1897–1965), U.S. congressman from Missouri •
William H. Cole IV (born 1972), city councilman from Baltimore •
William Hinson Cole (1837–1886), U.S. congressman from Maryland and Confederate surgeon •
William Purington Cole Jr. (1889–1957), U.S. congressman from Maryland and judge •
W. Sterling Cole (1904–1987), U.S. congressman from New York •
William J. Cole, state treasurer of Mississippi •
Bill Cole (Montana politician), mayor of Billings, Montana, 2017 •
Bill Cole (West Virginia politician) (born 1956), member of the West Virginia Senate ==Religion==