In 1844 Gregg embarked to the North, on a mission to study and examine the numerous
textile mills in Massachusetts, Connecticut, Vermont, and New Hampshire. Gregg wanted to improve and enhance the industry in the South as many Southern plants were prone to failure and undercapitalized. Following his return to Charleston, Gregg was very active in the community. William Gregg wrote a series of articles that appeared in the local paper, the
Charleston Courier. In these articles, Gregg outlined ways by which businessmen in the South could invest and prosper in manufacturing. Gregg advocated that the region stop remaining over-dependent on plantation agriculture as the only means of commerce in the society. The articles mainly critiqued the South's failure to develop a strong and viable manufacturing sector that could accompany the strengths of the agricultural industry, specifically plantations. Gregg became a leading advocate for industrialization in the South; he published these articles in a pamphlet that was called "Essays on Domestic Industry". This work strongly attacked planters for allowing their ventures to die through inattention and undercapitalization. Gregg's ultimate vision saw the Business capitalists of the South guiding industry and development through applying industry, prudence, and a surplus of capital to manufacturing plants and manufacturing operations. Gregg became committed to the idea that South Carolina and the South were wasting potential by shipping Raw cotton to the North and buying back these goods at inflated prices. Gregg felt that by keeping local capital, the state would diversify, jobs would be produced, and the economy would become less dependent on cotton growing. In December 1845, Gregg was able to convince the South Carolina legislature to charter the Graniteville Mill, which became the South's largest and most well known cotton mill. With a group of Charleston elite, the group was granted an initial capitalization of $300,0000. This money was put towards constructing a tremendous and massive state of the art textile factory and plant on Horse creek, which was a couple of miles from Gregg's Vaucluse Mill. The production and construction of the Graniteville Company relied on the local people of the area to build and operate the mill. Farmers, tenants, and the poor were employed with wages similar to those of Northern mill workers. When full operations ceased in 1849, the Graniteville Company mill was one of, if not the largest
textile mills in the South. The plant contained more than nine thousand spindles and three hundred looms, and produced around twelve thousand yards of cloth per day. These products were sold across the continent and in markets reaching New York and Philadelphia. ==Later life==