On April 16, 1844, • William Worthen Appleton (1845–1924), who married Anna Debois Sargent (1845–1908). in 1872. • Mary Appleton (d. 1934), who died unmarried. • Henry Cozzens Appleton (1863–1925), who married Dora Threlkeld (1847–1927). Appleton was a prominent figure in publishing for a period of sixty years. He lived at
Wave Hill (New York); the house was later turned into a
botanical garden in the
Riverdale section of
The Bronx, New York. He was one of the earliest members of the
Century Association, joining in 1847, a member of the
Union Club of New York, the Riding Club, and the Aldine and Players' Clubs. He is buried in
Woodlawn Cemetery in The Bronx.
Descendants His grandson, through his son William, was William Henry Appleton (1866–1951), a prominent yachtsman who married Noel Johnston, granddaughter of
John Taylor Johnston, former president of the
Central Railroad of New Jersey and the founding president of
The Metropolitan Museum of Art.
Legacy Appleton City, Missouri, was named after the publisher, in appreciation of his 1870 donation to the town's library. ==In popular culture==