Hope-Johnstone is a surname. Notable people with the surname include:James Hope-Johnstone, 3rd Earl of Hopetoun (1741–1816), Scottish peer John Hope-Johnstone (disambiguation), multiple people Patrick Hope-Johnstone, 11th Earl of Annandale and Hartfell, Scottish peer Percy Wentworth Hope-Johnstone (1909–1983), de jure British peer and army soldier William Hope-Johnstone (1798–1878), British navy commander