Lane began his academic career as professor of New Testament and Judaic studies at
Gordon-Conwell Theological Seminary. He went on to serve as professor of religious studies at
Western Kentucky University for fifteen years. During this time, he became a mentor to Christian singer and songwriter
Michael Card. He was also recognized with the faculty award for "Distinguished Contributions in Research or Creativity" for the 1983–1984 academic year. Lane joined the faculty of
Seattle Pacific University as dean of the School of Religion in 1989. He was named "Professor of the Year" by the student body in 1992, and served as the Paul T. Walls Chair in Wesleyan and Biblical Studies from 1993 until his retirement in 1997. In addition to these roles, Lane also served as one of the translators of the
New American Standard Bible, and the
New International Version. ==Death and legacy==