At the age of 28, Smellie was hired by
Colin Macfarquhar and
Andrew Bell to edit the first edition of the
Encyclopædia Britannica, which appeared in 100 weekly instalments ("numbers") from December 1768 to 1771 (reissued together in 1771 in 3 volumes). It was a masterful composition although, by Smellie's own admission, Nevertheless, the first edition of the
Britannica contained gross inaccuracies and fanciful speculations; for example, it states that excess use of tobacco could cause
neurodegeneration, "drying up the brain to a little black lump consisting of mere membranes". Smellie strove to make
Britannica as usable as possible, saying that "utility ought to be the principal intention of every publication. Wherever this intention does not plainly appear, neither the books nor their authors have the smallest claim to the approbation of mankind". Smellie entertained strong opinions; for example, he defines
farriery as "the art of curing the diseases of horses. The practice of this useful art has been hitherto almost entirely confined to a set of men who are totally ignorant of anatomy, and the general principles of medicine." Although possessed of wide knowledge, Smellie was not an expert in all matters; for example, his article on "
Woman" has but four words: "the female of man." some prurient engravings by
Andrew Bell (later
censored by
King George III) may also have contributed to the success of the first edition. Smellie did not participate in the second edition of the
Britannica, because he objected to the inclusion of biographical articles in an
encyclopedia dedicated to the arts and sciences. ==Later work and death==