Byrne was born in
Florida, Montgomery County, New York, and was the son of Richard Henry Byrne, a carpenter, and Margaret Manifold Byrne, a school teacher, both of whom were immigrants from Ireland. His family moved to Albany when he was an infant, and his father operated a bar and grill on
Broadway while Byrne attended the city's public schools. Byrne spoke frequently at public events and developed a nationwide reputation as an orator on behalf of these and other organizations. In
1922 and
1924, Byrne nominated
Al Smith for governor at the state Democratic convention. In
1938, he was called upon to nominate
Herbert H. Lehman for reelection as governor. Active in politics as a Democrat, Byrne was one of the lieutenants employed by
Daniel P. O'Connell when he developed the party organization that wrested control of the city and county of Albany from longtime Republican boss
William Barnes Jr. Byrne was also active physically throughout his life, golfing frequently and undertaking difficult hikes and walking trips. For most of life, he made the annual 35 mile trip between his Albany-area home and his summer home in Montgomery County on foot. In November 1951, one of his U.S. House colleagues noted that Byrne marched the entire length of a four mile Veterans Day parade in Albany, after which he delivered two speeches in commemoration of the holiday. ==State senator==