Washington Nationals Difo signed with the
Washington Nationals as an international free agent on June 3, 2010. He made his professional debut that season for the
Dominican Summer League Nationals. From 2010 to 2013, he played for the
Gulf Coast Nationals,
Auburn Doubledays,
Hagerstown Suns and
Potomac Nationals. Difo played the 2014 season with Hagerstown. He was named the 2014
South Atlantic League Most Valuable Player (MVP) with a .315
batting average, a .360
on-base percentage and a .470
slugging average, with 14
home runs and 90
runs batted in. He received the
Bob Boone Award from the Nationals, which "recognizes professionalism and passion". Difo started 2015 with the Potomac Nationals and was promoted to the Double-A Harrisburg Senators after 19 games. On May 19, 2015, Difo was called up to the major leagues for the first time and collected his first hit in his first at-bat the same day, a pinch-hit single up the middle off
New York Yankees reliever
David Carpenter. Difo hit his first career home run on September 29, 2016, off
Arizona Diamondbacks starter and former Nationals pitching prospect
Robbie Ray. On October 14, 2016, he struck out for the game's last out as a pinch hitter as the
Los Angeles Dodgers defeated the Nationals 4–3 to win the National League Division Series. Difo received his first career start in the outfield on June 24, 2017, playing center field against the
Cincinnati Reds due to an injury to regular center fielder
Michael A. Taylor. After
Trea Turner suffered a broken wrist in a game days later, Difo took over as the Nationals' regular starting shortstop, occasionally sharing duties with
Stephen Drew and
Adrián Sánchez. On July 27, 2017, Difo hit one of four consecutive home runs by Nationals hitters off
Milwaukee Brewers starter
Michael Blazek, the first time the feat had been accomplished in Major League Baseball since the
2011 season. Splitting time between the Majors and Minors in 2019, Difo appeared in 43 games with the Nationals and had a .252 average with two home runs and eight RBIs. The Nationals finished the year with a 93–69 record, able to clinch a wild card spot. Difo did not play in the postseason, but was on the Nationals' 40-man roster when the team won the
2019 World Series over the
Houston Astros, their first championship in franchise history. On September 5, 2020, Difo was designated for assignment by the Nationals. He cleared waivers and was assigned to the team's alternate training site in
Fredericksburg,
Virginia. Difo elected free agency on October 13, 2020.
Pittsburgh Pirates On January 15, 2021, Difo signed a minor league contract with the
Pittsburgh Pirates organization. On April 4, 2021, Difo was selected to the 40-man roster to fill in for
Ke'Bryan Hayes, who was suffering from left wrist inflammation. On May 22, 2021, against the
Atlanta Braves, Difo pitched one inning in a blowout, giving up eight runs on six hits, including a grand slam. It was his first career pitching appearance. On June 8, Difo was designated for assignment after posting a .244/.287/.366 batting line in 44 games for the Pirates. He was outrighted to the Triple-A
Indianapolis Indians on June 12. Difo was re-selected to the active roster on July 2. Difo hit .269/.329/.384 with 4 home runs and 24 RBI in 116 games for the Pirates. On November 6, 2021, Difo was outrighted from the 40-man roster and elected free agency the next day.
Arizona Diamondbacks On March 19, 2022, Difo signed a minor league contract with the
Arizona Diamondbacks. In 74 appearances split between the rookie-level
Arizona Complex League Diamondbacks and Triple-A
Reno Aces, he batted .269/.315/.396 with seven home runs, 43 RBI, and four stolen bases. On September 1, the Diamondbacks selected Difo's contract, adding him to their active roster. He played in three games for Arizona, going hitless across six plate appearances. On September 12, Difo was designated for assignment by the Diamondbacks. He cleared waivers on September 19, but elected free agency in lieu of an outright assignment to Triple-A Reno.
New York Yankees On December 23, 2022, Difo signed a minor league deal with the
New York Yankees. He played in 96 games for the Triple–A
Scranton/Wilkes-Barre RailRiders, hitting .208/.322/.303 with five home runs, 24 RBI, and 23 stolen bases. Difo elected free agency following the season on November 6, 2023.
Chicago White Sox On April 13, 2024, Difo signed a minor league contract with the
Chicago White Sox. In 94 appearances for the Triple-A
Charlotte Knights, he slashed .276/.370/.405 with seven home runs, 44 RBI, and 11 stolen bases. Difo elected free agency following the season on November 4.
Guerreros de Oaxaca On April 24, 2025, Difo signed with the
Guerreros de Oaxaca of the
Mexican League. In 59 appearances for Oaxaca, he batted .284/.381/.372 with two home runs, 23 RBI, and four stolen bases. Difo was released by the Guerreros on July 11.
Leones de Yucatán On July 11, 2025, Difo was claimed off waivers by the
Leones de Yucatán of the
Mexican League. He played in 22 games for the Leones, hitting .273/.455/.288 with no home runs, six RBI, and three stolen bases. Difo was released by Yucatán on December 18.
Long Island Ducks On April 7, 2026, Difo signed with the
Long Island Ducks of the
Atlantic League of Professional Baseball. ==Personal life==