The station replaced an earlier station erected by the
Philadelphia, Wilmington and Baltimore Railroad. It was built in 1907 for $300,000 (equal to $ today) by the PW&B successor, the
Pennsylvania Railroad. Admired for his use of new and innovative materials and his forceful architectural statements, Furness chose to have the trains move right through the second floor of the station, with room for a ticketing and retail concourse at ground level underneath the tracks. A renovation project was conducted in 1984. In 2009, the station began a two-year restoration; about two-thirds of the $37.7 million in funding came from
United States government stimulus funds. During construction, customer operations, including platform access, were moved to a temporary station next door. On March 19, 2011, the station's name was changed from Wilmington Station to Joseph R. Biden, Jr., Railroad Station. The ceremony honored U.S. Vice President (and later President)
Joe Biden, who took over 7,000 round trips from the station to
Washington, D.C. during his U.S. Senate career and was noted as an advocate for Amtrak and passenger rail more generally. On January 20, 2017, within an hour after completing his tenure as vice president, Biden boarded an Amtrak
Acela train in Washington, D.C. bound for his namesake station. The adjacent Wilmington Transit Center for DART First State bus service opened in May 2020. A $11.6 million renovation of the station, which included two new escalators, was completed in October 2023. == Services ==