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Windkessel effect

Windkessel effect is a term used in medicine to account for the shape of the arterial blood pressure waveform in terms of the interaction between the stroke volume and the compliance of the aorta and large elastic arteries and the resistance of the smaller arteries and arterioles. Windkessel when loosely translated from German to English means 'air chamber', but is generally taken to imply an elastic reservoir. The walls of large elastic arteries contain elastic fibers, formed of elastin. These arteries distend when the blood pressure rises during systole and recoil when the blood pressure falls during diastole. Since the rate of blood entering these elastic arteries exceeds that leaving them via the peripheral resistance, there is a net storage of blood in the aorta and large arteries during systole, which discharges during diastole. The compliance of the aorta and large elastic arteries is therefore analogous to a capacitor ; to put it another way, these arteries collectively act as a hydraulic accumulator.

Model types
Modeling of a Windkessel Windkessel physiology remains a relevant yet dated description of important clinical interest. The historic mathematical definition of systole and diastole in the model are obviously not novel but are here elementally staged to four degrees. Reaching five would be original work. Two-element It is assumed that the ratio of pressure to volume is constant and that outflow from the Windkessel is proportional to the fluid pressure. Volumetric inflow must equal the sum of the volume stored in the capacitive element and volumetric outflow through the resistive element. This relationship is described by a differential equation: I(t)={P(t)\over R}+C{dP(t)\over dt} I(t) is volumetric inflow due to the pump (heart) and is measured in volume per unit time, while P(t) is the pressure with respect to time measured in force per unit area, C is the ratio of volume to pressure for the Windkessel, and R is the resistance relating outflow to fluid pressure. This model is identical to the relationship between current, I(t), and electrical potential, P(t), in an electrical circuit equivalent of the two-element Windkessel model. In the blood circulation, the passive elements in the circuit are assumed to represent elements in the cardiovascular system. The resistor, R, represents the total peripheral resistance and the capacitor, C, represents total arterial compliance. During diastole there is no blood inflow since the aortic (or pulmonary valve) is closed, so the Windkessel can be solved for P(t) since I(t) = 0: P(t)=P(t_d)e^{-(t-t_d)\over (RC)} where td is the time of the start of diastole and P(td) is the blood pressure at the start of diastole. This model is only a rough approximation of the arterial circulation; more realistic models incorporate more elements, provide more realistic estimates of the blood pressure waveform and are discussed below. Three-element The three-element Windkessel improves on the two-element model by incorporating another resistive element to simulate resistance to blood flow due to the characteristic resistance of the aorta (or pulmonary artery). The differential equation for the 3-element model is: (1+{R_1\over R_2})I(t)+CR_1{dI(t)\over dt}= {P(t)\over R_2}+C{dP(t)\over dt} where R1 is the characteristic resistance (this is assumed to be equivalent to the characteristic impedance), and the pulmonary artery in a pig Four-element The three-element model overestimates the compliance and underestimates the characteristic impedance of the circulation. The four-element model includes an inductor, L, which has units of mass per length, ({M\over l^4}), into the proximal component of the circuit to account for the inertia of blood flow. This is neglected in the two- and three- element models. The relevant equation is: (1+{R_1\over R_2})I(t)+(R_1C+{L\over R_2}){dI(t)\over dt}+LC{d^2I(t)\over dt^2}={P(t)\over R_2}+C{dP(t)\over dt} == Applications ==
Applications
These models relate blood flow to blood pressure through parameters of R, C (and, in the case of the four-element model, L). These equations can be easily solved (e.g. by employing MATLAB and its supplement SIMULINK) to either find the values of pressure given flow and R, C, L parameters, or find values of R, C, L given flow and pressure. An example for the two-element model is shown below, where I(t) is depicted as an input signal during systole and diastole. Systole is represented by the sin function, while flow during diastole is zero. s represents the duration of the cardiac cycle, while Ts represents the duration of systole, and Td represents the duration of diastole (e.g. in seconds). I(t)=I_o\sin[{(\pi*{t\over s})\over Ts}] \text{ for } {t\over s}\leq Ts I(t)=0\text{ for } Ts In physiology and disease The 'Windkessel effect' becomes diminished with age as the elastic arteries become less compliant, termed hardening of the arteries or arteriosclerosis, probably secondary to fragmentation and loss of elastin. The reduction in the Windkessel effect results in increased pulse pressure for a given stroke volume. The increased pulse pressure results in elevated systolic pressure (hypertension) which increases the risk of myocardial infarction, stroke, heart failure and a variety of other cardiovascular diseases. == Limitations ==
Limitations
Although the Windkessel is a simple and convenient concept, it has been largely superseded by more modern approaches that interpret arterial pressure and flow waveforms in terms of wave propagation and reflection. Recent attempts to integrate wave propagation and Windkessel approaches through a reservoir concept, have been criticized and a recent consensus document highlighted the wave-like nature of the reservoir. ==See also==
Source: Wikipedia ↗
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