Wygal was a founding member of the Fellowship of Socialist Christians, along with her YWCA colleague
Rose Terlin. She worked for the YWCA from 1911 to 1944, and was a member of the YWCA's national professional staff from 1918, when she joined the War Work Council. She was national executive of the YWCA's Student Council from 1922 to 1935. In 1935 she joined the Laboratory Division, and co-chaired the Fletcher Farm Seminar on Religion with
Gregory Vlastos. She toured as a lecturer and community organizer in her retirement, and chaired the editorial board of
The Intercollegian, the national magazine of the YWCA's Student Council. Wygal traveled across the United States and internationally in her work. She met
Gandhi and
Rabindranath Tagore in India, and was a delegate to the World Student Federation Conference in
Mysore, during a year of sabbatical travels in 1927 and 1928. In 1928 she was in the Middle East, and in 1937 she went to England to attend a
World Council of Churches conference at Oxford. Traveling was very important to her, as it was a way for her to "broaden the psychological space around" her. Fertig and Perry both appeared frequently in Wygal’s diaries. ==Authorship of the
Serenity Prayer==