The highway starts at
WIS 11 in Monroe and tracks northeasterly. It then passes through
Albany and then
runs concurrently with
WIS 104 for near Magnolia Bluff Park. It then heads east and runs concurrently with
WIS 213 for until reaching
US Highway 14 (US 14) in
Evansville, where WIS 213 terminates. WIS 59 remains concurrent with US 14 until reaching
Union then heads east through
Cooksville and
Edgerton, then junctions with
Interstate 39/
Interstate 90 (I-90/I-90) and then crossing the
Rock River near
Newville. It then heads southeasterly, passing through
Milton and then going east and northeast to
Whitewater. The route runs concurrently with
US 12 for about , then passes through the north and east sides of Whitewater before continuing east. It then passes through
Palmyra,
Eagle, and
North Prairie before looping south of
Waukesha. The eastern and southern portion of the bypass highway around Waukesha (
US 18 and WIS 59/
WIS 164) is dedicated as the Les Paul Parkway in honor of
Les Paul. WIS 59 runs parallel to
I-94 entering
Milwaukee County, routed along National Avenue and Greenfield Avenue, then terminates at
WIS 32 south of downtown
Milwaukee. == Major intersections ==