The reign of her predecessor,
Mae Ku, saw
Lan Na transition into a
vassal state of the
Toungoo empire. In 1564, she was installed as
queen regnant by
Bayinnaung, in response to Mekuti's refusal to join Bayinnaung's military campaign against
Ayutthaya, which was seen by Bayinnaung as an act of rebellion. Throughout her fourteen-year reign, Lan Na enjoyed political stability, and Wisutthithewi offered tribute to the Toungoo empire, in exchange for political stability in her dominion, However, no other Burmese or Lan Na sources corroborate any marriage between Bayinnaung and Wisutthithewi; moreover, no Chiang Mai princess is listed among Bayinnaung's queens and concubines in these sources. == Death ==