Development Development rights to
Anne Rice's
Lives of the Mayfair Witches book series were still held by
Warner Bros in December 2019, when Rice began shopping a package combining film and TV rights to both
The Vampire Chronicles and
Mayfair Witches. Rice was reportedly asking around $30 to $40 million, plus a $2.5 million buyout of Warner Bros.' rights, and the new owner would hold the rights in perpetuity, not just as an option. Anne and
Christopher Rice would serve as executive producers on any projects developed. Rice said, "It's always been my dream to see the worlds of my two biggest series united under a single roof so that filmmakers could explore the expansive and interconnected universe of my vampires and witches. That dream is now a reality, and the result is one of the most significant and thrilling deals of my long career." Spalding and Ashford said, "The world of witches has fascinated and terrified for centuries, and yet Anne Rice's particular lens on witches explored something new altogether—women who are powerful, and often brutal, and always committed to subverting our current power structures." On February 3, 2023, AMC renewed the series for a second season. On April 9, 2025, AMC renewed the series for a third season, with adding
Thomas Schnauz as a co-showrunner.
Casting In March 2022,
Variety reported that
Alexandra Daddario had been cast in the lead role of Dr. Rowan Fielding. Dan McDermott, president of entertainment and AMC Studios for AMC Networks, said "Alexandra is a singular talent who has lit up the screen in everything she's been in and we couldn't be happier to have her on board, leading the cast of a series that will be a centerpiece of an expanding Anne Rice universe on AMC+ and AMC. We found our Rowan and can't wait for her to meet viewers later this year".
Harry Hamlin joined the cast that same month as patriarch Cortland Mayfair. In April 2022, AMC announced the casting of series regular
Tongayi Chirisa as Ciprien Grieve, as well as
Annabeth Gish as Deirdre Mayfair,
Beth Grant as Carlotta Mayfair,
Erica Gimpel as Ellie Mayfair and
Jen Richards as Jojo, in recurring roles. In May 2022,
Jack Huston was cast as Lasher, described as one of Rice's "most mysterious and sensual characters—a powerful, shape-shifting entity who has been bound to the Mayfair witches for hundreds of years." Alyssa Jirrels joined the second season as a series regular playing Rowan's cousin, Moira Mayfair. She is described as a mind reader, "who blames the family and Lasher for the death of her sister Tessa".
Ted Levine was cast in a recurring guest starring role as Julien Mayfair, Cortland and Carlotta's father, and "a master manipulator".
Thora Birch guest stars as Gifford Mayfair, "a self-deprecating tarot card reader".
Ben Feldman was cast as Sam Larkin, the CEO of a genetics startup and Rowan's former boyfriend. In October 2025,
Betsy Brandt joined the cast as new series regular for the third season. In November 2025,
James Frain and
Eliza Scanlen were cast as new series regulars for the third season. In December 2025,
Omar Maskati joined the cast as a series regular for the third season.
Filming Filming of the first season of
Mayfair Witches took place in
New Orleans from April 25 to August 26, 2022. The second season was scheduled to film from January 29 to April 5, 2024. Filming for the third season began on October 20, 2025, and concluded on February 20, 2026, in
Vancouver,
British Columbia. ==Release==