Wogonin has been found in one study to have
anxiolytic properties in mice at doses of 7.5 to 30 mg/kg, without exhibiting the sedative and muscle-relaxing properties of benzodiazepines. Wogonin has also been found to possess
anticonvulsant effects. It acts as a
positive allosteric modulator of the
benzodiazepine site of the
GABAA receptor with a binding affinity of Ki 0.92 μM and an IC50 value of 1.26 μM which is about 100 times less potent than
diazepam (IC50 value of 0.012 μM). CNS review: ==See also==